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There are many oral therapies for erectile dysfunction, but the only approved medication in the US is the PDE 5 enzyme inhibitor sildenafil Viagra. Unapproved therapies, some of which are available in the US and some elsewhere, some of which have data to prove efficacy and some not, include tadalafil Cialisvardenafil Levitrayohimbine, phentolamine, trazodone, apomorphine and neutraceuticals. PDE5 inhibitors act to relax penile erectile tissues with sexual stimulation thus enhancing your ability to get an erection. Why is there a need for another pill? Structurally vardenafil Levitra is similar to sildenafil, while tadalafil Cialis is very different. Vardenafil Levitra is almost 10 times more biochemically potent than sildenafil, therefore a lower dose is needed to facilitate the penile erection, potentially resulting in less side effects.
Selectivity is the ability of the drug to attach to the specific enzyme PDE 5 found in penile tissues. Vardenafil Levitra is more selective than sildenafil and tadalafil Cialis to PDE5, which again means a lower dose is needed with potentially less side effects.
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